488 research outputs found
Evs and bioengineering: From cellular products to engineered nanomachines
Extracellular vesicles (EVs) are natural carriers produced by many different cell types that have a plethora of functions and roles that are still under discovery. This review aims to be a compendium on the current advancement in terms of EV modifications and re-engineering, as well as their potential use in nanomedicine. In particular, the latest advancements on artificial EVs are discussed, with these being the frontier of nanomedicine-based therapeutics. The first part of this review gives an overview of the EVs naturally produced by cells and their extraction methods, focusing on the possibility to use them to carry desired cargo. The main issues for the production of the EV-based carriers are addressed, and several examples of the techniques used to upload the cargo are provided. The second part focuses on the engineered EVs, obtained through surface modification, both using direct and indirect methods, i.e., engineering of the parental cells. Several examples of the current literature are proposed to show the broad variety of engineered EVs produced thus far. In particular, we also report the possibility to engineer the parental cells to produce cargo-loaded EVs or EVs displaying specific surface markers. The third and last part focuses on the most recent advancements based on synthetic and chimeric EVs and the methods for their production. Both top-down or bottom-up techniques are analyzed, with many examples of applications
Multi-colour optical monitoring of eight red blazars
We present the observational results of multi-colour optical monitoring of
eight red blazars from 2003 September to 2004 February. The aim of our
monitoring is to investigate the spectral variability as well as the flux
variations at short and long time scales. The observations were carried out
using the 1.0 m robotic telescope of Mt. Lemmon Optical Astronomy Observatory,
in Arizona, USA, the 0.6 m telescope of Sobaeksan Optical Astronomy Observatory
and the 1.8 m telescope of Bohyunsan Optical Astronomy Observatory, in the
Republic of Korea. During the observations, all sources show strong flux
variations with amplitudes of larger than 0.5 mag. Variations with amplitudes
of over 1 mag are found in four sources. Intraday variations with amplitudes
larger than 0.15 mag, and a rapid brightness increase with a rate of ~0.2 mag
per day in four days, are detected in S5 0716+71. We investigate the
relationship between the colour index and source brightness for each source. We
find that two out of three FSRQs tend to be redder when they are brighter, and,
conversely, all BL Lac objects tend to be bluer. In particular, we find a
significant anti-correlation between the V-I colour index and R magnitude for
3C 454.3. This implies that the spectrum became steeper when the source was
brighter, which is opposite to the common trend for blazars. In contrast,
significant positive correlations are found in 3C 66A, S5 0716+71, and BL Lac.
However, there are only very weak correlations for PKS 0735+17 and OJ 287. We
propose that the different relative contributions of the thermal versus
non-thermal radiation to the optical emission may be responsible for the
different trends of the colour index with brightness in FSRQs and BL Lac
objects.Comment: 15 pages, 12 figures. Accepted for publication in A&
Optical variability of the BL Lacertae object GC 0109+224. Multiband behaviour and time scales from a 7-years monitoring campaign
We present the most continuous data base of optical
observations ever published on the BL Lacertae object GC 0109+224, collected
mainly by the robotic telescope of the Perugia University Observatory in the
period November 1994-February 2002. These observations have been complemented
by data from the Torino Observatory, collected in the period July 1995-January
1999, and Mt. Maidanak Observatory (December 2000). GC 0109+224 showed rapid
optical variations and six major outbursts were observed at the beginning and
end of 1996, in fall 1998, at the beginning and at the end of 2000, and at the
beginning of 2002. Fast and large-amplitude drops characterized its flux
behaviour. The magnitude ranged from 13.3 (16.16 mJy) to 16.46 (0.8 mJy),
with a mean value of 14.9 (3.38 mJy). In the periods where we collected
multi-filter observations, we analyzed colour and spectral indexes, and the
variability patterns during some flares. The long-term behaviour seems
approximatively achromatic, but during some isolated outbursts we found
evidence of the typical loop-like hysteresis behaviour, suggesting that rapid
optical variability is dominated by non-thermal cooling of a single emitting
particle population. We performed also a statistical analysis of the data,
through the discrete correlation function (DCF), the structure function (SF),
and the Lomb-Scargle periodogram, to identify characteristic times scales, from
days to months, in the light curves, and to quantify the mode of variability.
We also include the reconstruction of the historical light curve and a
photometric calibration of comparison stars, to favour further extensive
optical monitoring of this interesting blazar.Comment: 13 pages, 11 PS figures, 1 EPS figure, 3 tables, accepted by
Astronomy and Astrophysics. Uses A&A documentclass aa.cls, and the package
graphicx.st
A dataset independent set of baselines for relation prediction in argument mining.
Argument Mining is the research area which aims at extracting argument components and predicting argumentative relations (i.e.,support and attack) from text. In particular, numerous approaches have been proposed in the literature to predict the relations holding between the arguments, and application-specific annotated resources were built for this purpose. Despite the fact that these resources have been created to experiment on the same task, the definition of a single relation prediction method to be successfully applied to a significant portion of these datasets is an open research problem in Argument Mining. This means that none of the methods proposed in the literature can be easily ported from one resource to another. In this paper, we address this problem by proposing a set of dataset independent strong neural baselines which obtain homogeneous results on all the datasets proposed in the literature for the argumentative relation prediction task. Thus, our baselines can be employed by the Argument Mining community to compare more effectively how well a method performs on the argumentative relation prediction task
Modelling dialogues for optimal legislation
This paper presents a framework for modelling legislative deliberation in the form of dialogues. Roughly, in legislative dialogues coalitions can dynamically change and propose rule-based theories associated with different utility functions, depending on the legislative theory the coalitions are trying to determine
Gamma-ray blazars: the view from AGILE
During the first 3 years of operation the Gamma-Ray Imaging Detector onboard
the AGILE satellite detected several blazars in a high gamma-ray activity: 3C
279, 3C 454.3, PKS 1510-089, S5 0716+714, 3C 273, W Comae, Mrk 421, PKS
0537-441 and 4C +21.35. Thanks to the rapid dissemination of our alerts, we
were able to obtain multiwavelength data from other observatories such as
Spitzer, Swift, RXTE, Suzaku, INTEGRAL, MAGIC, VERITAS, and ARGO as well as
radio-to-optical coverage by means of the GASP Project of the WEBT and the REM
Telescope. This large multifrequency coverage gave us the opportunity to study
the variability correlations between the emission at different frequencies and
to obtain simultaneous spectral energy distributions of these sources from
radio to gamma-ray energy bands, investigating the different mechanisms
responsible for their emission and uncovering in some cases a more complex
behaviour with respect to the standard models. We present a review of the most
interesting AGILE results on these gamma-ray blazars and their multifrequency
data.Comment: 25 pages, 10 figures, accepted for publication on Advances in Space
Research. Talk presented at the 38th COSPAR Scientific Assembly (Bremen,
Germany; July 18-25, 2010
Axisymmetric equilibria of a gravitating plasma with incompressible flows
It is found that the ideal magnetohydrodynamic equilibrium of an axisymmetric
gravitating magnetically confined plasma with incompressible flows is governed
by a second-order elliptic differential equation for the poloidal magnetic flux
function containing five flux functions coupled with a Poisson equation for the
gravitation potential, and an algebraic relation for the pressure. This set of
equations is amenable to analytic solutions. As an application, the
magnetic-dipole static axisymmetric equilibria with vanishing poloidal plasma
currents derived recently by Krasheninnikov, Catto, and Hazeltine [Phys. Rev.
Lett. {\bf 82}, 2689 (1999)] are extended to plasmas with finite poloidal
currents, subject to gravitating forces from a massive body (a star or black
hole) and inertial forces due to incompressible sheared flows. Explicit
solutions are obtained in two regimes: (a) in the low-energy regime
, where
, , , and are related to the thermal,
poloidal-current, flow and gravitating energies normalized to the
poloidal-magnetic-field energy, respectively, and (b) in the high-energy regime
. It turns out
that in the high-energy regime all four forces, pressure-gradient,
toroidal-magnetic-field, inertial, and gravitating contribute equally to the
formation of magnetic surfaces very extended and localized about the symmetry
plane such that the resulting equilibria resemble the accretion disks in
astrophysics.Comment: 12 pages, latex, to be published in Geophys. Astrophys. Fluid
Dynamic
Multifrequency monitoring of the blazar 0716+714 during the GASP-WEBT-AGILE campaign of 2007
Since the CGRO operation in 1991-2000, one of the primary unresolved
questions about the blazar gamma-ray emission has been its possible correlation
with the low-energy (in particular optical) emission. To help answer this
problem, the Whole Earth Blazar Telescope (WEBT) consortium has organized the
GLAST-AGILE Support Program (GASP) to provide the optical-to-radio monitoring
data to be compared with the gamma-ray detections by the AGILE and GLAST
satellites. This new WEBT project started in early September 2007, just before
a strong gamma-ray detection of 0716+714 by AGILE. We present the GASP-WEBT
optical and radio light curves of this blazar obtained in July-November 2007,
about various AGILE pointings at the source. We construct NIR-to-UV spectral
energy distributions (SEDs), by assembling GASP-WEBT data together with UV data
from the Swift ToO observations of late October. We observe a contemporaneous
optical-radio outburst, which is a rare and interesting phenomenon in blazars.
The shape of the SEDs during the outburst appears peculiarly wavy because of an
optical excess and a UV drop-and-rise. The optical light curve is well sampled
during the AGILE pointings, showing prominent and sharp flares. A future
cross-correlation analysis of the optical and AGILE data will shed light on the
expected relationship between these flares and the gamma-ray events.Comment: 5 pages, 5 figures, to be published in A&A (Letters); revised to
match the final version (changes in Fig. 5 and related text
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